Phoenix Sky Harbor is 162 miles and approximately 2 1/2 hour drive.  The route is about 1/5 highway driving through city traffic and 4/5 highway open desert traffic on Hwy 10.  There are more scenic options via Wickenburg or Salome Rd but they will add time to your drive.  Wide range of airlines to choose from. 

Phoenix-Mesa Gateway Airport is 193 miles and approximately 3 hours 10 minutes drive.  The route is about 1/4 highway driving through city traffic and 3/4 highway open desert traffic on Hwy 10.  There is a more scenic option through Wickenburg but it will add about 20 minutes to your drive.  Allegiant Air flies into this airport.  

Henry Reid International Airport, Las Vegas, NV is 175 miles of mostly scenic desert 2 lane highways.  The drive is approximately 3 hours.  Many airline options including some of the budget ones (Southwest, Allegiant Air, etc)

Palm Springs International Airport is 155 miles and approximately 2 hours and 40 minutes via Hwy 10.  Or the more scenic option on Hwy 62 will add about 15 minutes but is a nice quiet 2 lane hwy.